From Millstone to Stepping Stone

A Stepping Stone to Pluripotency

Somatic cells can be reprogrammed into pluripotent stem cells via either expression of transcription factors or addition of small molecule chemicals only. Zhao et al. reveal a unique intermediate state during chemical reprogramming allowing a significant improvement in its efficiency and kinetics.

Stepping Stone Detection Analysis

Imitation as a Stepping Stone to Innovation

By creating a knowledge base that reduces innovation costs, imitation can serve as a stepping stone enabling …rms from lagging countries to undertake innovation. This paper constructs a product cycle model with this feature to determine what forces could cause a lagging country to shift R&D from imitation toward innovation. Increasing resources or subsidizing R&D in the lagging South increases ...

Intelligent Network-Based Stepping Stone Detection Approach

This research intends to introduce a new usage of Artificial Intelligent (AI) approaches in Stepping Stone Detection (SSD) fields of research. By using Self-Organizing Map (SOM) approaches as the engine, through the experiment, it is shown that SOM has the capability to detect the number of connection chains that involved in a stepping stones. Realizing that by counting the number of connection...

A stepping stone in treating dendritic keratitis

Purpose To report the outcome of self-retained amniotic membrane after debridement in recurrent dendritic keratitis. Observations A 70-year-old female with a recurrent dendritic corneal ulcer received debridement followed by placement of self-retained amniotic membrane. Five days after treatment, the patient experienced a complete resolution of symptoms, marked reduction of inflammation, comp...